Title |
Preoperative conventional chemoradiotherapy versus short-course radiotherapy with delayed surgery for rectal cancer: results of a randomized controlled trial
|
---|---|
Published in |
BMC Cancer, December 2016
|
DOI | 10.1186/s12885-016-2959-9 |
Pubmed ID | |
Authors |
Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis, Dainius Pavalkis |
Abstract |
There still is no evidence which neoadjuvant therapy regimen for stage II-III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy (CRT) with short-term radiotherapy (RT) followed by delayed surgery. A randomized trial was carried out between 2007-2013. One hundred fifty patients diagnosed with stage II-III rectal cancer were randomized into one of two neoadjuvant treatment arms: conventional chemoradiotherapy (CRT) and short-term radiotherapy (RT) followed by surgery after 6-8 weeks. Primary endpoints of this trial were downstaging and pathological complete response rate. Secondary endpoints were local recurrence rate and overall survival. The pathological complete response was found in 3 (4.4%) cases after RT and 8 (11.1%) after CRT (P = 0.112). Downstaging (stage 0 and I) was observed in 21 (30.9%) cases in RT group vs. 27 (37.5%) cases in CRT group (P = 0.409). Median follow-up time was 39.7 (range 4.9-79.7) months. 3-years overall survival (OS) was 78% in RT group vs. 82.4% in CRT group (P = 0.145), while disease-free survival (DFS) differed significantly - 59% in RT group vs. 75.1% in CRT group (P = 0,022). Hazard ratio of cancer progression for RT patients was 1.93 (95% CI: 1.08-3.43) compared to CRT patients. Three-years disease-free survival was better in CRT group comparing with RT group with no difference in overall survival. http://clinicaltrials.gov identifier NCT00597311. January 2008. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 6 | 55% |
Algeria | 1 | 9% |
Germany | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 91% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 9 | 13% |
Student > Master | 7 | 10% |
Researcher | 6 | 9% |
Other | 6 | 9% |
Student > Ph. D. Student | 5 | 7% |
Other | 13 | 19% |
Unknown | 22 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 47% |
Nursing and Health Professions | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 1% |
Arts and Humanities | 1 | 1% |
Other | 2 | 3% |
Unknown | 26 | 38% |