Title |
Dynamic modeling of yeast meiotic initiation
|
---|---|
Published in |
BMC Systems Biology, May 2013
|
DOI | 10.1186/1752-0509-7-37 |
Pubmed ID | |
Authors |
Debjit Ray, Yongchun Su, Ping Ye |
Abstract |
Meiosis is the sexual reproduction process common to eukaryotes. The diploid yeast Saccharomyces cerevisiae undergoes meiosis in sporulation medium to form four haploid spores. Initiation of the process is tightly controlled by intricate networks of positive and negative feedback loops. Intriguingly, expression of early meiotic proteins occurs within a narrow time window. Further, sporulation efficiency is strikingly different for yeast strains with distinct mutations or genetic backgrounds. To investigate signal transduction pathways that regulate transient protein expression and sporulation efficiency, we develop a mathematical model using ordinary differential equations. The model describes early meiotic events, particularly feedback mechanisms at the system level and phosphorylation of signaling molecules for regulating protein activities. |
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