Title |
The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
|
---|---|
Published in |
Journal of Neuroinflammation, February 2023
|
DOI | 10.1186/s12974-023-02723-y |
Pubmed ID | |
Authors |
Yuxiang Xu, Yongjie Li, Changqing Wang, Tingting Han, Haixuan Liu, Lin Sun, Jun Hong, Makoto Hashimoto, Jianshe Wei |
Abstract |
In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the loss of dopaminergic neurons. So far, we have mainly focused on the role of the specific class of immune cells in PD while neglecting the impact of interactions among immune cells on the disease. Therefore, this review demonstrates the reciprocal interplays between microglia and T cells and the associated subpopulations through cytokine and chemokine production that impair and/or protect the pathological process of PD. Furthermore, potential targets and models of PD neuroinflammation are highlighted to provide the new ideas/directions for future research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 33% |
United States | 2 | 33% |
Italy | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 4 | 13% |
Student > Bachelor | 3 | 9% |
Student > Ph. D. Student | 3 | 9% |
Researcher | 3 | 9% |
Student > Postgraduate | 3 | 9% |
Other | 3 | 9% |
Unknown | 13 | 41% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 4 | 13% |
Neuroscience | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 4 | 13% |
Unknown | 14 | 44% |