Title |
A human Dravet syndrome model from patient induced pluripotent stem cells
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Published in |
Molecular Brain, May 2013
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DOI | 10.1186/1756-6606-6-19 |
Pubmed ID | |
Authors |
Norimichi Higurashi, Taku Uchida, Christoph Lossin, Yoshio Misumi, Yohei Okada, Wado Akamatsu, Yoichi Imaizumi, Bo Zhang, Kazuki Nabeshima, Masayuki X Mori, Shutaro Katsurabayashi, Yukiyoshi Shirasaka, Hideyuki Okano, Shinichi Hirose |
Abstract |
Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the α-subunit of the voltage-gated sodium channel Na(v)1.1. Disease modeling using patient-derived induced pluripotent stem cells (iPSCs) can be a powerful tool to reproduce this syndrome's human pathology. However, no such effort has been reported to date. We here report a cellular model for DS that utilizes patient-derived iPSCs. |
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Geographical breakdown
Country | Count | As % |
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Japan | 2 | 18% |
United Kingdom | 2 | 18% |
United States | 1 | 9% |
Unknown | 6 | 55% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 73% |
Science communicators (journalists, bloggers, editors) | 2 | 18% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 3 | 2% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Australia | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 186 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 46 | 24% |
Student > Ph. D. Student | 35 | 18% |
Student > Master | 16 | 8% |
Student > Bachelor | 14 | 7% |
Other | 12 | 6% |
Other | 40 | 21% |
Unknown | 31 | 16% |
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Neuroscience | 37 | 19% |
Medicine and Dentistry | 30 | 15% |
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Psychology | 11 | 6% |
Other | 12 | 6% |
Unknown | 43 | 22% |