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The clinical and epidemiological characteristics of a series of patients living with HIV admitted for COVID-19 in a district hospital

Overview of attention for article published in BMC Infectious Diseases, February 2023
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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Title
The clinical and epidemiological characteristics of a series of patients living with HIV admitted for COVID-19 in a district hospital
Published in
BMC Infectious Diseases, February 2023
DOI 10.1186/s12879-023-08004-6
Pubmed ID
Authors

Ayanda Trevor Mnguni, Denzil Schietekat, Nabilah Ebrahim, Nawhaal Sonday, Nicholas Boliter, Neshaad Schrueder, Shiraaz Gabriels, Lovemore N. Sigwadhi, Annalise E. Zemlin, Zivanai C. Chapanduka, Veranyuy Ngah, Anteneh Yalew, Thumeka Jalavu, Ibtisam Abdullah, Jacques L. Tamuzi, Yamanya Tembo, Mary-Ann Davies, Rene English, Peter S. Nyasulu

Abstract

The coronavirus disease 2019 (COVID-19) pandemic continues to evolve. Globally, COVID-19 continues to strain even the most resilient healthcare systems, with Omicron being the latest variant. We made a thorough search for literature describing the effects of the COVID-19 in a high human immunodeficiency virus (HIV)/tuberculosis (TB) burden district-level hospital setting. We found scanty literature. A retrospective observational study was conducted at Khayelitsha District Hospital in Cape Town, South Africa (SA) over the period March 2020-December 2021. We included confirmed COVID-19 cases with HIV infection aged from 18 years and above. Analysis was performed to identify predictors of mortality or hospital discharge among people living with HIV (PLWH). Predictors investigated include CD4 count, antiretroviral therapy (ART), TB, non-communicable diseases, haematological, and biochemical parameters. This cohort of PLWH with SARS-CoV-2 infection had a median (IQR) age of 46 (37-54) years, male sex distribution of 29.1%, and a median (IQR) CD4 count of 267 (141-457) cells/mm3. Of 255 patients, 195 (76%) patients were discharged, 60 (24%) patients died. One hundred and sixty-nine patients (88%) were on ART with 73(28%) patients having acquired immunodeficiency syndrome (AIDS). After multivariable analysis, smoking (risk ratio [RR]: 2.86 (1.75-4.69)), neutrophilia [RR]: 1.024 (1.01-1.03), and glycated haemoglobin A1 (HbA1c) [RR]: 1.01 (1.007-1.01) were associated with mortality. The district hospital had a high COVID-19 mortality rate among PLWH. Easy-to-access biomarkers such as CRP, neutrophilia, and HbA1c may play a significant role in informing clinical management to prevent high mortality due to COVID-19 in PLWH at the district-level hospitals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 7 16%
Student > Bachelor 4 9%
Researcher 3 7%
Other 2 5%
Librarian 2 5%
Other 4 9%
Unknown 21 49%
Readers by discipline Count As %
Unspecified 7 16%
Business, Management and Accounting 3 7%
Medicine and Dentistry 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 5 12%
Unknown 24 56%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2023.
All research outputs
#2,506,447
of 25,656,290 outputs
Outputs from BMC Infectious Diseases
#746
of 8,669 outputs
Outputs of similar age
#49,720
of 424,271 outputs
Outputs of similar age from BMC Infectious Diseases
#12
of 157 outputs
Altmetric has tracked 25,656,290 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,669 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,271 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.