Title |
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
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Published in |
Breast Cancer Research, July 2009
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DOI | 10.1186/bcr2333 |
Pubmed ID | |
Authors |
Bahriye Aktas, Mitra Tewes, Tanja Fehm, Siegfried Hauch, Rainer Kimmig, Sabine Kasimir-Bauer |
Abstract |
The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, these cells also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples of 39 metastatic breast cancer patients during a follow-up of palliative chemo-, antibody - or hormonal therapy for the expression of the stem cell marker ALDH1 and markers for EMT and correlated these findings with the presence of CTC and response to therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 6 | 1% |
Netherlands | 2 | <1% |
France | 2 | <1% |
Switzerland | 1 | <1% |
Chile | 1 | <1% |
Germany | 1 | <1% |
Sweden | 1 | <1% |
South Africa | 1 | <1% |
Singapore | 1 | <1% |
Other | 5 | 1% |
Unknown | 449 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 100 | 21% |
Student > Ph. D. Student | 99 | 21% |
Student > Master | 51 | 11% |
Student > Bachelor | 41 | 9% |
Student > Doctoral Student | 28 | 6% |
Other | 78 | 17% |
Unknown | 73 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 122 | 26% |
Medicine and Dentistry | 102 | 22% |
Biochemistry, Genetics and Molecular Biology | 90 | 19% |
Engineering | 32 | 7% |
Chemistry | 10 | 2% |
Other | 26 | 6% |
Unknown | 88 | 19% |