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Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

Overview of attention for article published in Breast Cancer Research, July 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
patent
9 patents

Citations

dimensions_citation
646 Dimensions

Readers on

mendeley
470 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
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Title
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
Published in
Breast Cancer Research, July 2009
DOI 10.1186/bcr2333
Pubmed ID
Authors

Bahriye Aktas, Mitra Tewes, Tanja Fehm, Siegfried Hauch, Rainer Kimmig, Sabine Kasimir-Bauer

Abstract

The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, these cells also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples of 39 metastatic breast cancer patients during a follow-up of palliative chemo-, antibody - or hormonal therapy for the expression of the stem cell marker ALDH1 and markers for EMT and correlated these findings with the presence of CTC and response to therapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 470 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 1%
Netherlands 2 <1%
France 2 <1%
Switzerland 1 <1%
Chile 1 <1%
Germany 1 <1%
Sweden 1 <1%
South Africa 1 <1%
Singapore 1 <1%
Other 5 1%
Unknown 449 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 100 21%
Student > Ph. D. Student 99 21%
Student > Master 51 11%
Student > Bachelor 41 9%
Student > Doctoral Student 28 6%
Other 78 17%
Unknown 73 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 122 26%
Medicine and Dentistry 102 22%
Biochemistry, Genetics and Molecular Biology 90 19%
Engineering 32 7%
Chemistry 10 2%
Other 26 6%
Unknown 88 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#2,474,660
of 25,371,288 outputs
Outputs from Breast Cancer Research
#238
of 2,052 outputs
Outputs of similar age
#8,532
of 121,794 outputs
Outputs of similar age from Breast Cancer Research
#1
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.