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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gut microbiome is linked to functions of peripheral immune cells in transition cows during excessive lipolysis
|
|---|---|
| Published in |
Microbiome, March 2023
|
| DOI | 10.1186/s40168-023-01492-3 |
| Pubmed ID | |
| Authors |
Fengfei Gu, Senlin Zhu, Yifan Tang, Xiaohan Liu, Minghui Jia, Nilusha Malmuthuge, Teresa G. Valencak, Joseph W. McFadden, Jian-Xin Liu, Hui-Zeng Sun |
| Abstract |
Postpartum dairy cows experiencing excessive lipolysis are prone to severe immunosuppression. Despite the extensive understanding of the gut microbial regulation of host immunity and metabolism, its role during excessive lipolysis in cows is largely unknown. Herein, we investigated the potential links between the gut microbiome and postpartum immunosuppression in periparturient dairy cows with excessive lipolysis using single immune cell transcriptome, 16S amplicon sequencing, metagenomics, and targeted metabolomics. The use of single-cell RNA sequencing identified 26 clusters that were annotated to 10 different immune cell types. Enrichment of functions of these clusters revealed a downregulation of functions in immune cells isolated from a cow with excessive lipolysis compared to a cow with low/normal lipolysis. The results of metagenomic sequencing and targeted metabolome analysis together revealed that secondary bile acid (SBA) biosynthesis was significantly activated in the cows with excessive lipolysis. Moreover, the relative abundance of gut Bacteroides sp. OF04 - 15BH, Paraprevotella clara, Paraprevotella xylaniphila, and Treponema sp. JC4 was mainly associated with SBA synthesis. The use of an integrated analysis showed that the reduction of plasma glycolithocholic acid and taurolithocholic acid could contribute to the immunosuppression of monocytes (CD14+MON) during excessive lipolysis by decreasing the expression of GPBAR1. Our results suggest that alterations in the gut microbiota and their functions related to SBA synthesis suppressed the functions of monocytes during excessive lipolysis in transition dairy cows. Therefore, we concluded that altered microbial SBA synthesis during excessive lipolysis could lead to postpartum immunosuppression in transition cows. Video Abstract. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 14% |
| Austria | 1 | 7% |
| Cyprus | 1 | 7% |
| Spain | 1 | 7% |
| Unknown | 9 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 86% |
| Scientists | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 7% |
| Researcher | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Student > Master | 1 | 7% |
| Unknown | 10 | 71% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 21% |
| Mathematics | 1 | 7% |
| Unknown | 10 | 71% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2023.
All research outputs
#1,629,778
of 25,443,857 outputs
Outputs from Microbiome
#589
of 1,762 outputs
Outputs of similar age
#33,673
of 423,962 outputs
Outputs of similar age from Microbiome
#14
of 69 outputs
Altmetric has tracked 25,443,857 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,762 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,962 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.