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Assessment of blinding to treatment allocation in studies of a cannabis-based medicine (Sativex®) in people with multiple sclerosis: a new approach

Overview of attention for article published in Trials, October 2012
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Title
Assessment of blinding to treatment allocation in studies of a cannabis-based medicine (Sativex®) in people with multiple sclerosis: a new approach
Published in
Trials, October 2012
DOI 10.1186/1745-6215-13-189
Pubmed ID
Authors

Stephen Wright, Paul Duncombe, Douglas G Altman

Abstract

Maintenance of the blind-to-treatment allocation is one of the most important means of avoiding bias in randomised controlled clinical trials. Commonly used methodologies to determine whether patients have become unblinded to treatment allocation are imperfect. This may be of particular concern in studies where outcomes are patient-reported, and with products which have a characteristic adverse event profile. We report the results of an evidence-based statistical approach to exploring the possible impact of unblinding to a cannabis-based medicine (Sativex®) in people with muscle spasticity due to multiple sclerosis.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 122 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 14%
Student > Bachelor 17 14%
Student > Ph. D. Student 16 13%
Student > Master 13 10%
Student > Postgraduate 10 8%
Other 27 22%
Unknown 24 19%
Readers by discipline Count As %
Medicine and Dentistry 36 29%
Agricultural and Biological Sciences 12 10%
Psychology 11 9%
Nursing and Health Professions 8 6%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Other 23 18%
Unknown 28 22%