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The personalized cancer network explorer (PeCaX) as a visual analytics tool to support molecular tumor boards

Overview of attention for article published in BMC Bioinformatics, March 2023
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Title
The personalized cancer network explorer (PeCaX) as a visual analytics tool to support molecular tumor boards
Published in
BMC Bioinformatics, March 2023
DOI 10.1186/s12859-023-05194-3
Pubmed ID
Authors

Mirjam Figaschewski, Bilge Sürün, Thorsten Tiede, Oliver Kohlbacher

Abstract

Personalized oncology represents a shift in cancer treatment from conventional methods to target specific therapies where the decisions are made based on the patient specific tumor profile. Selection of the optimal therapy relies on a complex interdisciplinary analysis and interpretation of these variants by experts in molecular tumor boards. With up to hundreds of somatic variants identified in a tumor, this process requires visual analytics tools to guide and accelerate the annotation process. The Personal Cancer Network Explorer (PeCaX) is a visual analytics tool supporting the efficient annotation, navigation, and interpretation of somatic genomic variants through functional annotation, drug target annotation, and visual interpretation within the context of biological networks. Starting with somatic variants in a VCF file, PeCaX enables users to explore these variants through a web-based graphical user interface. The most protruding feature of PeCaX is the combination of clinical variant annotation and gene-drug networks with an interactive visualization. This reduces the time and effort the user needs to invest to get to a treatment suggestion and helps to generate new hypotheses. PeCaX is being provided as a platform-independent containerized software package for local or institution-wide deployment. PeCaX is available for download at https://github.com/KohlbacherLab/PeCaX-docker .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 30%
Student > Ph. D. Student 2 20%
Student > Doctoral Student 1 10%
Student > Master 1 10%
Unknown 3 30%
Readers by discipline Count As %
Computer Science 3 30%
Biochemistry, Genetics and Molecular Biology 1 10%
Agricultural and Biological Sciences 1 10%
Business, Management and Accounting 1 10%
Immunology and Microbiology 1 10%
Other 1 10%
Unknown 2 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2023.
All research outputs
#16,237,425
of 25,654,566 outputs
Outputs from BMC Bioinformatics
#5,043
of 7,734 outputs
Outputs of similar age
#217,417
of 425,553 outputs
Outputs of similar age from BMC Bioinformatics
#87
of 139 outputs
Altmetric has tracked 25,654,566 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,734 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,553 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.