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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
|
|---|---|
| Published in |
Journal of Translational Medicine, March 2023
|
| DOI | 10.1186/s12967-023-04041-6 |
| Pubmed ID | |
| Authors |
Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Juli Rodriguez Bago, Roman Hájek, Matouš Hrdinka |
| Abstract |
Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological malignancies. Ectopically expressed chimeric antigen receptors (CARs) reprogram immune cells to target and eliminate cancer. However, CAR T cell therapy's success depends on the balance between effective anti-tumor activity and minimizing harmful side effects. To improve CAR T cell therapy outcomes and mitigate associated toxicities, scientists from different fields are cooperating in developing next-generation products using the latest molecular cell biology and synthetic biology tools and technologies. The immunotherapy field is rapidly evolving, with new approaches and strategies being reported at a fast pace. This comprehensive literature review aims to provide an up-to-date overview of the latest developments in controlling CAR T cell activity for improved safety, efficacy, and flexibility. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 5 | 45% |
| United States | 2 | 18% |
| India | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 64% |
| Scientists | 3 | 27% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 22% |
| Researcher | 4 | 11% |
| Unspecified | 3 | 8% |
| Student > Ph. D. Student | 3 | 8% |
| Lecturer | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 15 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 3 | 8% |
| Unspecified | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Engineering | 3 | 8% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 18 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 189. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2023.
All research outputs
#198,678
of 24,457,696 outputs
Outputs from Journal of Translational Medicine
#55
of 4,376 outputs
Outputs of similar age
#4,971
of 410,780 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 149 outputs
Altmetric has tracked 24,457,696 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 410,780 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.