Title |
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation
|
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Published in |
BMC Genomics, January 2010
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DOI | 10.1186/1471-2164-11-25 |
Pubmed ID | |
Authors |
David O Azorsa, RiLee H Robeson, Danielle Frost, Bessie Meec hoovet, Gillian R Brautigam, Chad Dickey, Christian Beaudry, Gargi D Basu, David R Holz, Joseph A Hernandez, Kristen M Bisanz, Leslie Gwinn, Andrew Grover, Joseph Rogers, Eric M Reiman, Michael Hutton, Dietrich A Stephan, Spyro Mousses, Travis Dunckley |
Abstract |
Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-related residues. Identifying the kinases involved in the pathologic phosphorylation of tau may provide targets at which to aim new AD-modifying treatments. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Australia | 1 | <1% |
India | 1 | <1% |
Japan | 1 | <1% |
Unknown | 102 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 37% |
Student > Ph. D. Student | 20 | 19% |
Student > Master | 12 | 11% |
Student > Bachelor | 9 | 8% |
Other | 6 | 6% |
Other | 11 | 10% |
Unknown | 10 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 36% |
Biochemistry, Genetics and Molecular Biology | 17 | 16% |
Neuroscience | 15 | 14% |
Chemistry | 7 | 6% |
Medicine and Dentistry | 5 | 5% |
Other | 11 | 10% |
Unknown | 14 | 13% |