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The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study

Overview of attention for article published in BMC Veterinary Research, May 2013
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  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Title
The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study
Published in
BMC Veterinary Research, May 2013
DOI 10.1186/1746-6148-9-94
Pubmed ID
Authors

Arianna Aricò, Mery Giantin, Maria Elena Gelain, Fulvio Riondato, Stefano Comazzi, Barbara C Rütgen, Sabine E Essler, Mauro Dacasto, Massimo Castagnaro, Luca Aresu

Abstract

Canine lymphoma represents the most frequent haematopoietic cancer and it shares some similarities with human non-Hodgkin lymphoma. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play a coordinated role during invasion and proliferation of malignant cells; however, little is known about their role in canine haematologic malignancies. The aim of this study was to investigate the mRNA and protein expression of VEGF and the most relevant MMPs in canine lymphoma. Lymph node aspirates from 26 B-cell and 21 T-cell lymphomas were collected. The protein expression levels of MMP-9, MMP-2 and VEGF-A were evaluated by immunocytochemistry, and the mRNA levels of MMP-2, MMP-9, MT1-MMP, TIMP-1, TIMP-2, RECK, VEGF-A and VEGF-164 were measured using quantitative RT-PCR.

X Demographics

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 13 20%
Other 8 12%
Student > Ph. D. Student 8 12%
Researcher 6 9%
Student > Master 6 9%
Other 12 18%
Unknown 12 18%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 28 43%
Medicine and Dentistry 13 20%
Agricultural and Biological Sciences 6 9%
Unspecified 2 3%
Computer Science 1 2%
Other 2 3%
Unknown 13 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2013.
All research outputs
#13,889,326
of 22,709,015 outputs
Outputs from BMC Veterinary Research
#1,016
of 3,037 outputs
Outputs of similar age
#106,262
of 192,814 outputs
Outputs of similar age from BMC Veterinary Research
#13
of 48 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,037 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,814 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.