Title |
The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study
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Published in |
BMC Veterinary Research, May 2013
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DOI | 10.1186/1746-6148-9-94 |
Pubmed ID | |
Authors |
Arianna Aricò, Mery Giantin, Maria Elena Gelain, Fulvio Riondato, Stefano Comazzi, Barbara C Rütgen, Sabine E Essler, Mauro Dacasto, Massimo Castagnaro, Luca Aresu |
Abstract |
Canine lymphoma represents the most frequent haematopoietic cancer and it shares some similarities with human non-Hodgkin lymphoma. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play a coordinated role during invasion and proliferation of malignant cells; however, little is known about their role in canine haematologic malignancies. The aim of this study was to investigate the mRNA and protein expression of VEGF and the most relevant MMPs in canine lymphoma. Lymph node aspirates from 26 B-cell and 21 T-cell lymphomas were collected. The protein expression levels of MMP-9, MMP-2 and VEGF-A were evaluated by immunocytochemistry, and the mRNA levels of MMP-2, MMP-9, MT1-MMP, TIMP-1, TIMP-2, RECK, VEGF-A and VEGF-164 were measured using quantitative RT-PCR. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 64 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 13 | 20% |
Other | 8 | 12% |
Student > Ph. D. Student | 8 | 12% |
Researcher | 6 | 9% |
Student > Master | 6 | 9% |
Other | 12 | 18% |
Unknown | 12 | 18% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 28 | 43% |
Medicine and Dentistry | 13 | 20% |
Agricultural and Biological Sciences | 6 | 9% |
Unspecified | 2 | 3% |
Computer Science | 1 | 2% |
Other | 2 | 3% |
Unknown | 13 | 20% |