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p38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes

Overview of attention for article published in Molecular Pain, January 2010
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Title
p38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes
Published in
Molecular Pain, January 2010
DOI 10.1186/1744-8069-6-28
Pubmed ID
Authors

Hsinlin T Cheng, Jacqueline R Dauch, Sang Su Oh, John M Hayes, Yu Hong, Eva L Feldman

Abstract

Painful Diabetic Neuropathy (PDN) affects more than 25% of patients with type 2 diabetes; however, the pathogenesis remains unclear due to lack of knowledge of the molecular mechanisms leading to PDN. In our current study, we use an animal model of type 2 diabetes in order to understand the roles of p38 in PDN. Previously, we have demonstrated that the C57BLK db/db (db/db) mouse, a model of type 2 diabetes that carries the loss-of-function leptin receptor mutant, develops mechanical allodynia in the hind paws during the early stage (6-12 wk of age) of diabetes. Using this timeline of PDN, we can investigate the signaling mechanisms underlying mechanical allodynia in the db/db mouse.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 22%
Researcher 6 13%
Professor 6 13%
Student > Master 5 11%
Student > Doctoral Student 3 7%
Other 8 17%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 26%
Neuroscience 10 22%
Medicine and Dentistry 9 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Immunology and Microbiology 1 2%
Other 2 4%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2013.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Molecular Pain
#372
of 669 outputs
Outputs of similar age
#143,826
of 172,626 outputs
Outputs of similar age from Molecular Pain
#24
of 30 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,626 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.