Title |
p38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes
|
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Published in |
Molecular Pain, January 2010
|
DOI | 10.1186/1744-8069-6-28 |
Pubmed ID | |
Authors |
Hsinlin T Cheng, Jacqueline R Dauch, Sang Su Oh, John M Hayes, Yu Hong, Eva L Feldman |
Abstract |
Painful Diabetic Neuropathy (PDN) affects more than 25% of patients with type 2 diabetes; however, the pathogenesis remains unclear due to lack of knowledge of the molecular mechanisms leading to PDN. In our current study, we use an animal model of type 2 diabetes in order to understand the roles of p38 in PDN. Previously, we have demonstrated that the C57BLK db/db (db/db) mouse, a model of type 2 diabetes that carries the loss-of-function leptin receptor mutant, develops mechanical allodynia in the hind paws during the early stage (6-12 wk of age) of diabetes. Using this timeline of PDN, we can investigate the signaling mechanisms underlying mechanical allodynia in the db/db mouse. |
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