Title |
Exploration of lung mycobiome in the patients with non-small-cell lung cancer
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Published in |
BMC Microbiology, March 2023
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DOI | 10.1186/s12866-023-02790-4 |
Pubmed ID | |
Authors |
Yiming Zhao, Junqi Yi, Juanjuan Xiang, Wei Jia, Anqi Chen, Liyu Chen, Leliang Zheng, Wen Zhou, Minghua Wu, Zheng Yu, Jingqun Tang |
Abstract |
As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied the alteration in lung mycobiome in patients with non-small-cell lung cancer (NSCLC) using metagenomic sequencing and qPCR. The higher fungal diversity and more complex network were observed in the patients with NSCLC. In addition, Alternaria arborescens was found as the most relevant fungus to NSCLC, and the enrichment of it in cancerous tissue was also detected. This study proposes that the changes in fungal communities may be closely related to lung cancer, and provides insights into further exploration the relationship between lung cancer and fungi. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Student > Bachelor | 1 | 11% |
Researcher | 1 | 11% |
Student > Master | 1 | 11% |
Other | 0 | 0% |
Unknown | 3 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Immunology and Microbiology | 1 | 11% |
Neuroscience | 1 | 11% |
Chemistry | 1 | 11% |
Engineering | 1 | 11% |
Other | 0 | 0% |
Unknown | 3 | 33% |