Title |
Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
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Published in |
Veterinary Research, March 2023
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DOI | 10.1186/s13567-023-01156-y |
Pubmed ID | |
Authors |
Niels Vander Elst, Julie Bellemans, Jonas Steenbrugge, Chloë Geeroms, Koen Breyne, Sofie Piepers, Bruno Toledo-Silva, Fernando Nogueira de Souza, Freddy Haesebrouck, Sarne De Vliegher, Evelyne Meyer |
Abstract |
Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus staphylococci are proposed in that respect due to their capacity to inhibit the in vitro growth of S. uberis. We demonstrate that priming the murine mammary gland with Staphylococcus chromogenes IM reduces S. uberis growth in comparison with non-primed glands. The innate immune system is activated by increasing IL-8 and LCN2, which may explain this decreased growth. |
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Sweden | 1 | 50% |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
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Unknown | 2 | 100% |
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Student > Master | 1 | 50% |
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Veterinary Science and Veterinary Medicine | 1 | 50% |
Unknown | 1 | 50% |