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Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19

Overview of attention for article published in European Journal of Medical Research, March 2023
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Title
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Published in
European Journal of Medical Research, March 2023
DOI 10.1186/s40001-023-01086-7
Pubmed ID
Authors

Kentaro Wakamatsu, Zenzo Nagasawa, Kouta Katsuki, Hiroyuki Kumazoe, Masayo Yasuda, Sae Kawamoto, Ayano Kawamura, Tsuyoshi Ueno, Ruriko Kiyotani, Izumi Fukui, Sanae Maki, Nobuhiko Nagata, Masayuki Kawasaki, Hozumi Yamada

Abstract

Pathogenic genetic testing for coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity; however, there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing. The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with nonrespiratory infection, one patient with a viral infection, 11 patients who had received treatment for COVID-19, one patient in contact with COVID-19 patients, and 59 patients with noninfectious disease). The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2-33.6), and the median MDW in 232 patients in the non-COVID-19 group was 19.0 (13.6-30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all mild, moderate I, and moderate II disease. MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients. Trial registration This study was conducted after being approved by the ethics committee of National Hospital Organization Omuta National Hospital (Approval No. 3-19). This study can be accessed via https://omuta.hosp.go.jp/files/000179721.pdf .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 33%
Student > Ph. D. Student 1 17%
Unspecified 1 17%
Unknown 2 33%
Readers by discipline Count As %
Unspecified 1 17%
Economics, Econometrics and Finance 1 17%
Medicine and Dentistry 1 17%
Engineering 1 17%
Unknown 2 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2023.
All research outputs
#15,184,741
of 25,394,764 outputs
Outputs from European Journal of Medical Research
#340
of 924 outputs
Outputs of similar age
#189,892
of 421,786 outputs
Outputs of similar age from European Journal of Medical Research
#10
of 41 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 924 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.