Title |
Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis
|
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Published in |
Journal of Nanobiotechnology, March 2023
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DOI | 10.1186/s12951-023-01865-8 |
Pubmed ID | |
Authors |
Ke Rui, Xiaoxuan Tang, Ziwei Shen, Chao Jiang, Qiugang Zhu, Shiyi Liu, Nan Che, Jie Tian, Jue Ling, Yumin Yang |
Abstract |
Although exosome therapy has been recognized as a promising strategy in the treatment of rheumatoid arthritis (RA), sustained modulation on RA specific pathogenesis and desirable protective effects for attenuating joint destruction still remain challenges. Here, silk fibroin hydrogel encapsulated with olfactory ecto-mesenchymal stem cell-derived exosomes (Exos@SFMA) was photo-crosslinked in situ to yield long-lasting therapeutic effect on modulating the immune microenvironment in RA. This in situ hydrogel system exhibited flexible mechanical properties and excellent biocompatibility for protecting tissue surfaces in joint. Moreover, the promising PD-L1 expression was identified on the exosomes, which potently suppressed Tfh cell polarization via inhibiting the PI3K/AKT pathway. Importantly, Exos@SFMA effectively relieved synovial inflammation and joint destruction by significantly reducing T follicular helper (Tfh) cell response and further suppressing the differentiation of germinal center (GC) B cells into plasma cells. Taken together, this exosome enhanced silk fibroin hydrogel provides an effective strategy for the treatment of RA and other autoimmune diseases. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 19% |
Student > Master | 2 | 13% |
Researcher | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Unknown | 9 | 56% |
Readers by discipline | Count | As % |
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Philosophy | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Other | 1 | 6% |
Unknown | 10 | 63% |