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X Demographics
Mendeley readers
Attention Score in Context
| Title |
APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
|
|---|---|
| Published in |
Journal of Hematology & Oncology, March 2023
|
| DOI | 10.1186/s13045-023-01425-5 |
| Pubmed ID | |
| Authors |
Kelly Butler, A. Rouf Banday |
| Abstract |
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine deaminases involved in innate and adaptive immunity. However, some APOBEC family members can also deaminate host genomes to generate oncogenic mutations. The resulting mutations, primarily signatures 2 and 13, occur in many tumor types and are among the most common mutational signatures in cancer. This review summarizes the current evidence implicating APOBEC3s as major mutators and outlines the exogenous and endogenous triggers of APOBEC3 expression and mutational activity. The review also discusses how APOBEC3-mediated mutagenesis impacts tumor evolution through both mutagenic and non-mutagenic pathways, including by inducing driver mutations and modulating the tumor immune microenvironment. Moving from molecular biology to clinical outcomes, the review concludes by summarizing the divergent prognostic significance of APOBEC3s across cancer types and their therapeutic potential in the current and future clinical landscapes. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 35% |
| Italy | 3 | 9% |
| India | 2 | 6% |
| Turkey | 2 | 6% |
| Colombia | 1 | 3% |
| United Kingdom | 1 | 3% |
| Peru | 1 | 3% |
| Unknown | 12 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 59% |
| Scientists | 10 | 29% |
| Practitioners (doctors, other healthcare professionals) | 4 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 8% |
| Student > Master | 2 | 5% |
| Other | 1 | 3% |
| Student > Doctoral Student | 1 | 3% |
| Unspecified | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 27 | 69% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Agricultural and Biological Sciences | 4 | 10% |
| Unspecified | 1 | 3% |
| Materials Science | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 27 | 69% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2023.
All research outputs
#1,807,528
of 25,589,756 outputs
Outputs from Journal of Hematology & Oncology
#128
of 1,298 outputs
Outputs of similar age
#36,564
of 423,229 outputs
Outputs of similar age from Journal of Hematology & Oncology
#4
of 32 outputs
Altmetric has tracked 25,589,756 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,298 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,229 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.