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X Demographics
Mendeley readers
Attention Score in Context
| Title |
BIND&MODIFY: a long-range method for single-molecule mapping of chromatin modifications in eukaryotes
|
|---|---|
| Published in |
Genome Biology, March 2023
|
| DOI | 10.1186/s13059-023-02896-y |
| Pubmed ID | |
| Authors |
Zhe Weng, Fengying Ruan, Weitian Chen, Zhichao Chen, Yeming Xie, Meng Luo, Zhe Xie, Chen Zhang, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Chen Tan, Wenfang Chen, Yiqin Tong, Yaning Li, Hongqi Wang, Chong Tang |
| Abstract |
Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and represent the average chromatin state. Here we describe BIND&MODIFY, a method using long-read sequencing for profiling histone modifications and transcription factors on individual DNA fibers. We use recombinant fused protein A-M.EcoGII to tether methyltransferase M.EcoGII to protein binding sites to label neighboring regions by methylation. Aggregated BIND&MODIFY signal matches bulk ChIP-seq and CUT&TAG. BIND&MODIFY can simultaneously measure histone modification status, transcription factor binding, and CpG 5mC methylation at single-molecule resolution and also quantifies correlation between local and distal elements. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 13% |
| United Kingdom | 2 | 9% |
| Norway | 1 | 4% |
| Netherlands | 1 | 4% |
| Unknown | 16 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 70% |
| Scientists | 6 | 26% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 3 | 18% |
| Student > Master | 3 | 18% |
| Student > Ph. D. Student | 2 | 12% |
| Researcher | 2 | 12% |
| Professor > Associate Professor | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 5 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 53% |
| Agricultural and Biological Sciences | 4 | 24% |
| Unknown | 4 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2023.
All research outputs
#2,139,559
of 25,394,764 outputs
Outputs from Genome Biology
#1,793
of 4,470 outputs
Outputs of similar age
#42,521
of 421,862 outputs
Outputs of similar age from Genome Biology
#37
of 89 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.