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Mendeley readers
| Title |
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2activation
|
|---|---|
| Published in |
BMC Biology, February 2008
|
| DOI | 10.1186/1741-7007-6-8 |
| Pubmed ID | |
| Authors |
Clive Bate, Mourad Tayebi, Alun Williams |
| Abstract |
The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation of PrPSc within the brain leads to neurodegeneration through an unidentified mechanism. Since many neurodegenerative disorders including prion, Parkinson's and Alzheimer's diseases may be modified by cholesterol synthesis inhibitors, the effects of prion infection on the cholesterol balance within neuronal cells were examined. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 17% |
| Researcher | 5 | 17% |
| Professor | 4 | 13% |
| Professor > Associate Professor | 4 | 13% |
| Student > Bachelor | 3 | 10% |
| Other | 6 | 20% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 47% |
| Biochemistry, Genetics and Molecular Biology | 8 | 27% |
| Immunology and Microbiology | 2 | 7% |
| Psychology | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 10% |