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Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2activation

Overview of attention for article published in BMC Biology, February 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
30 Mendeley
citeulike
1 CiteULike
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Title
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2activation
Published in
BMC Biology, February 2008
DOI 10.1186/1741-7007-6-8
Pubmed ID
Authors

Clive Bate, Mourad Tayebi, Alun Williams

Abstract

The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation of PrPSc within the brain leads to neurodegeneration through an unidentified mechanism. Since many neurodegenerative disorders including prion, Parkinson's and Alzheimer's diseases may be modified by cholesterol synthesis inhibitors, the effects of prion infection on the cholesterol balance within neuronal cells were examined.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Researcher 5 17%
Professor 4 13%
Professor > Associate Professor 4 13%
Student > Bachelor 3 10%
Other 6 20%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 47%
Biochemistry, Genetics and Molecular Biology 8 27%
Immunology and Microbiology 2 7%
Psychology 1 3%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2008.
All research outputs
#5,480,800
of 25,986,827 outputs
Outputs from BMC Biology
#30
of 30 outputs
Outputs of similar age
#25,562
of 177,302 outputs
Outputs of similar age from BMC Biology
#3
of 6 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30 research outputs from this source. They receive a mean Attention Score of 4.1. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.