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DNAJB7 is dispensable for male fertility in mice

Overview of attention for article published in Reproductive Biology and Endocrinology, March 2023
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Title
DNAJB7 is dispensable for male fertility in mice
Published in
Reproductive Biology and Endocrinology, March 2023
DOI 10.1186/s12958-023-01086-6
Pubmed ID
Authors

Shun Bai, Meihong Hu, Lina Yu, Linjun Chen, Jidong Zhou, Limin Wu, Bo Xu, Xiaohua Jiang, Xindong Zhang, Xianhong Tong, Qiuling Yue

Abstract

DNAJBs are highly conserved proteins that are involved in various biological processes. Although several DNAJBs are highly expressed in the testis, the function of DNAJB7 in spermatogenesis and male fertility remains unclear. To identify the role of DNAJB7 in the male reproduction process, Dnajb7-deficient mice were generated by the CRISPR/Cas9-mediated genome editing system. Histological and immunofluorescence assays were performed to analyze the phenotype of the Dnajb7 mutants. DNAJB7 is specifically expressed in haploid germ cells. Dnajb7 knockout mice are fertile and do not have any detectable defects in Sertoli cells, spermatogonia, meiotic and postmeiotic cells, indicating that DNAJB7 is not essential for spermatogenesis. Our findings suggest that DNAJB7 is dispensable for male fertility in mice, which could prevent duplicative work by other groups.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2023.
All research outputs
#15,826,004
of 23,509,253 outputs
Outputs from Reproductive Biology and Endocrinology
#553
of 1,007 outputs
Outputs of similar age
#130,213
of 244,149 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#4
of 9 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,007 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.