Title |
The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
|
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Published in |
BMC Neuroscience, February 2005
|
DOI | 10.1186/1471-2202-6-6 |
Pubmed ID | |
Authors |
Bogdan Beirowski, Robert Adalbert, Diana Wagner, Daniela S Grumme, Klaus Addicks, Richard R Ribchester, Michael P Coleman |
Abstract |
The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on statistical observations at discontinuous locations within the nerve, without observing any single axon at two distant points. As axon degeneration is asynchronous, there are clear advantages to longitudinal studies of individual degenerating axons. We recently validated the study of Wallerian degeneration using yellow fluorescent protein (YFP) in a small, representative population of axons, which greatly improves longitudinal imaging. Here, we apply this method to study the progressive nature of Wallerian degeneration in both wild-type and slow Wallerian degeneration (WldS) mutant mice. |
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