Title |
Iterative rank-order normalization of gene expression microarray data
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Published in |
BMC Bioinformatics, May 2013
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DOI | 10.1186/1471-2105-14-153 |
Pubmed ID | |
Authors |
Eric A Welsh, Steven A Eschrich, Anders E Berglund, David A Fenstermacher |
Abstract |
Many gene expression normalization algorithms exist for Affymetrix GeneChip microarrays. The most popular of these is RMA, primarily due to the precision and low noise produced during the process. A significant strength of this and similar approaches is the use of the entire set of arrays during both normalization and model-based estimation of signal. However, this leads to differing estimates of expression based on the starting set of arrays, and estimates can change when a single, additional chip is added to the set. Additionally, outlier chips can impact the signals of other arrays, and can themselves be skewed by the majority of the population. |
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Unknown | 3 | 30% |
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Mendeley readers
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