Title |
Pros and cons of a prion-like pathogenesis in Parkinson's disease
|
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Published in |
BMC Neurology, June 2011
|
DOI | 10.1186/1471-2377-11-74 |
Pubmed ID | |
Authors |
Ruediger Hilker, Jonathan M Brotchie, Joab Chapman |
Abstract |
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex. A number of proteins are known to accumulate in parkinsonian brains including ubiquitin and α-synuclein. Prion diseases are sporadic, genetic or infectious disorders with various clinical and histopathological features caused by prion proteins as infectious proteinaceous particles transmitting a misfolded protein configuration through brain tissue. The most important form is Creutzfeldt-Jakob disease which is associated with a self-propagating pathological precursor form of the prion protein that is physiologically widely distributed in the central nervous system. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 82 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 26 | 31% |
Student > Ph. D. Student | 12 | 14% |
Student > Bachelor | 8 | 10% |
Professor | 5 | 6% |
Student > Doctoral Student | 5 | 6% |
Other | 17 | 20% |
Unknown | 10 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 33% |
Medicine and Dentistry | 21 | 25% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Neuroscience | 7 | 8% |
Social Sciences | 2 | 2% |
Other | 6 | 7% |
Unknown | 12 | 14% |