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High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide

Overview of attention for article published in Journal of Hematology & Oncology, November 2016
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
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Title
High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide
Published in
Journal of Hematology & Oncology, November 2016
DOI 10.1186/s13045-016-0354-2
Pubmed ID
Authors

Maryam Pourabdollah, Mohammad Bahmanyar, Eshetu G. Atenafu, Donna Reece, Jian Hou, Hong Chang

Abstract

The aim of this study is to assess nucleoprotein expression of IKZF1/3 in patients with relapsed/refractory multiple myeloma (MM) who received lenalidomide-based therapy and correlated them with their clinical outcomes. A total of 50 patients diagnosed with MM were entered in the study with the median follow-up of 86.4 months. By immunohistochemistry (IHC), IKZF1 and IKZF3 were expressed in 72 and 58% of the cases, respectively. IKZF1 and IKZF3 expressions were associated with longer median progression free survival (P = 0.0029 and P < 0.0001) and overall survival (P = 0.0014 and P < 0.0001). IKZF3 expression also appears predicted a favorable response to the lenalidomide-based therapy.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 25%
Researcher 5 25%
Student > Ph. D. Student 3 15%
Student > Doctoral Student 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 4 20%
Readers by discipline Count As %
Medicine and Dentistry 10 50%
Biochemistry, Genetics and Molecular Biology 3 15%
Neuroscience 1 5%
Nursing and Health Professions 1 5%
Unknown 5 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2017.
All research outputs
#13,372,303
of 23,567,572 outputs
Outputs from Journal of Hematology & Oncology
#621
of 1,223 outputs
Outputs of similar age
#200,246
of 418,232 outputs
Outputs of similar age from Journal of Hematology & Oncology
#12
of 20 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,223 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 418,232 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.