Title |
Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions
|
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Published in |
Lipids in Health and Disease, December 2016
|
DOI | 10.1186/s12944-016-0381-6 |
Pubmed ID | |
Authors |
Yuan Guo, Fei Luo, Yuhong Yi, Danyan Xu |
Abstract |
Atherosclerosis is a chronic inflammatory disease with complex pathological processes. MicroRNA-33 (miR-33), a novel non-coding RNA that coexpresses with sterol regulatory element-binding proteins (SREBPs), affects macrophage actions to prevent atherosclerosis. Fibroblast growth factor 21 (FGF21) is an important regulator of lipid metabolism, especially for macrophage-related cholesterol export, but the mechanism is not fully studied. Interestingly, FGF21 has been evidenced to prevent atherosclerosis via inhibiting SREBP-2 expression. Therefore, we speculate that FGF21 may be a potential regulator for miR-33 with an aim of insight into novel anti-atherosclerotic mechanisms and research fields. |
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United Kingdom | 1 | 50% |
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Unknown | 6 | 60% |