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Stromal cell derived factor-1alpha protects stem cell derived insulin-producing cells from glucotoxicity under high glucose conditions in-vitro and ameliorates drug induced diabetes in rats

Overview of attention for article published in Journal of Translational Medicine, May 2013
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Title
Stromal cell derived factor-1alpha protects stem cell derived insulin-producing cells from glucotoxicity under high glucose conditions in-vitro and ameliorates drug induced diabetes in rats
Published in
Journal of Translational Medicine, May 2013
DOI 10.1186/1479-5876-11-115
Pubmed ID
Authors

Muhammad Tariq, Muhammad Sharif Masoud, Azra Mehmood, Shaheen N Khan, Sheikh Riazuddin

Abstract

Diabetes mellitus is affecting more than 300 million people worldwide. Current treatment strategies cannot prevent secondary complications. Stem cells due to their regenerative power have long been the attractive target for the cell-based therapies. Mesenchymal stem cells (MSCs) possess the ability to differentiate into several cell types and to escape immune recognition in vitro. MSCs can be differentiated into insulin-producing cells (IPCs) and could be an exciting therapy for diabetes but problems like poor engraftment and survivability need to be confronted. It was hypothesized that stromal cell derived factor- 1alpha (SDF-1alpha) will enhance therapeutic potential of stem cell derived IPCs by increasing their survival and proliferation rate.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Master 5 17%
Student > Ph. D. Student 5 17%
Student > Bachelor 4 13%
Professor 3 10%
Other 3 10%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 12 40%
Agricultural and Biological Sciences 7 23%
Biochemistry, Genetics and Molecular Biology 2 7%
Psychology 1 3%
Engineering 1 3%
Other 0 0%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2013.
All research outputs
#17,687,671
of 22,709,015 outputs
Outputs from Journal of Translational Medicine
#2,734
of 3,970 outputs
Outputs of similar age
#138,620
of 193,144 outputs
Outputs of similar age from Journal of Translational Medicine
#42
of 47 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,970 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,144 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.