Title |
Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus
|
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Published in |
Gut Pathogens, December 2016
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DOI | 10.1186/s13099-016-0146-9 |
Pubmed ID | |
Authors |
Zhixing He, Tiejuan Shao, Haichang Li, Zhijun Xie, Chengping Wen |
Abstract |
Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of the gut microbiome in SLE patients from China is consistent with the intestinal dysbiosis of SLE patients from Spain. The depletion of Firmicutes and the enrichment of Bacteroidetes in SLE patients from China were consistent with the SLE patients from Spain. Furthermore, we found that nine genera of gut microbiota were SLE-related microorganisms in Chinese subjects. Genera Rhodococcus, Eggerthella, Klebsiella, Prevotella, Eubacterium, Flavonifractor and Incertae sedis were significantly enriched, while genera Dialister and Pseudobutyrivibrio were significantly depleted in SLE patients. Receiver operating characteristic analysis indicated that the nine genera have the potential to distinguish SLE patients from healthy controls. Comparing the dysbiosis of the gut microbiome among SLE patients from China or Spain, may indicate that the gut microbiome profiles of SLE patients are more influenced by disease than ethnicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 146 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 15% |
Student > Bachelor | 21 | 14% |
Student > Master | 17 | 12% |
Student > Ph. D. Student | 10 | 7% |
Student > Postgraduate | 9 | 6% |
Other | 18 | 12% |
Unknown | 49 | 34% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 17% |
Immunology and Microbiology | 21 | 14% |
Agricultural and Biological Sciences | 19 | 13% |
Biochemistry, Genetics and Molecular Biology | 10 | 7% |
Chemistry | 3 | 2% |
Other | 13 | 9% |
Unknown | 55 | 38% |