Title |
Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells
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Published in |
BMC Cancer, May 2013
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DOI | 10.1186/1471-2407-13-229 |
Pubmed ID | |
Authors |
Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa, Kazuhito Rokutan |
Abstract |
Vascular endothelial growth factor-a (VEGF)-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, however, the benefits are transiently, and the vast majority of patients who initially respond to the therapies will develop resistance. One of possible mechanisms for the acquired resistance may be the direct effect(s) of VEGF inhibitors on tumor cells expressing VEGF receptors (VEGFR). Thus, we investigated here the direct effect of chronic VEGF inhibition on phenotype changes in human colorectal cancer (CRC) cells. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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India | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 23% |
Student > Master | 7 | 16% |
Researcher | 6 | 14% |
Professor | 5 | 11% |
Student > Postgraduate | 3 | 7% |
Other | 7 | 16% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 23% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Immunology and Microbiology | 1 | 2% |
Energy | 1 | 2% |
Other | 3 | 7% |
Unknown | 8 | 18% |