Report for: On the origin of POU5F1

Title	On the origin of POU5F1
Published in	BMC Biology, May 2013
DOI	10.1186/1741-7007-11-56
Pubmed ID	23659605
Authors	Stephen Frankenberg, Marilyn B Renfree
Abstract	Pluripotency is a fundamental property of early mammalian development but it is currently unclear to what extent its cellular mechanisms are conserved in vertebrates or metazoans. POU5F1 and POU2 are the two principle members constituting the class V POU domain family of transcription factors, thought to have a conserved role in the regulation of pluripotency in vertebrates as well as germ cell maintenance and neural patterning. They have undergone a complex pattern of evolution which is poorly understood and controversial.

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On the origin of POU5F1