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Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine

Overview of attention for article published in BMC Veterinary Research, March 2013
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Title
Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine
Published in
BMC Veterinary Research, March 2013
DOI 10.1186/1746-6148-9-59
Pubmed ID
Authors

Aude Castel, Pierre Hélie, Francis Beaudry, Pascal Vachon

Abstract

Central post-stroke pain is a neuropathic pain condition caused by a vascular lesion, of either ischemic or hemorrhagic origin, in the central nervous system and more precisely involving the spinothalamocortical pathway responsible for the transmission of painful sensations. Few animal models have been developed to study this problem. The objectives of this study were to evaluate different modalities of pain in a central neuropathic pain rat model and to assess the effects of ketamine administered at different doses. Animals were evaluated on the rotarod, Hargreaves, Von Frey and acetone tests. A very small hemorrhage was created by injecting a collagenase solution in the right ventral posterolateral thalamic nucleus. Following the establishment of the neuropathy, ketamine was evaluated as a therapeutic drug for this condition.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Belgium 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Postgraduate 4 13%
Student > Master 4 13%
Student > Bachelor 3 10%
Lecturer 2 6%
Other 1 3%
Unknown 10 32%
Readers by discipline Count As %
Medicine and Dentistry 9 29%
Neuroscience 4 13%
Psychology 2 6%
Social Sciences 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 6%
Unknown 11 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2013.
All research outputs
#20,193,180
of 22,710,079 outputs
Outputs from BMC Veterinary Research
#2,410
of 3,037 outputs
Outputs of similar age
#172,998
of 197,844 outputs
Outputs of similar age from BMC Veterinary Research
#36
of 48 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,037 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,844 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.