Title |
Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine
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Published in |
BMC Veterinary Research, March 2013
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DOI | 10.1186/1746-6148-9-59 |
Pubmed ID | |
Authors |
Aude Castel, Pierre Hélie, Francis Beaudry, Pascal Vachon |
Abstract |
Central post-stroke pain is a neuropathic pain condition caused by a vascular lesion, of either ischemic or hemorrhagic origin, in the central nervous system and more precisely involving the spinothalamocortical pathway responsible for the transmission of painful sensations. Few animal models have been developed to study this problem. The objectives of this study were to evaluate different modalities of pain in a central neuropathic pain rat model and to assess the effects of ketamine administered at different doses. Animals were evaluated on the rotarod, Hargreaves, Von Frey and acetone tests. A very small hemorrhage was created by injecting a collagenase solution in the right ventral posterolateral thalamic nucleus. Following the establishment of the neuropathy, ketamine was evaluated as a therapeutic drug for this condition. |
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