Title |
Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains
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Published in |
BMC Genomics, May 2013
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DOI | 10.1186/1471-2164-14-316 |
Pubmed ID | |
Authors |
Vladimir Espinosa Angarica, Salvador Ventura, Javier Sancho |
Abstract |
Prion proteins conform a special class among amyloids due to their ability to transmit aggregative folds. Prions are known to act as infectious agents in neurodegenerative diseases in animals, or as key elements in transcription and translation processes in yeast. It has been suggested that prions contain specific sequential domains with distinctive amino acid composition and physicochemical properties that allow them to control the switch between soluble and β-sheet aggregated states. Those prion-forming domains are low complexity segments enriched in glutamine/asparagine and depleted in charged residues and prolines. Different predictive methods have been developed to discover novel prions by either assessing the compositional bias of these stretches or estimating the propensity of protein sequences to form amyloid aggregates. However, the available algorithms hitherto lack a thorough statistical calibration against large sequence databases, which makes them unable to accurately predict prions without retrieving a large number of false positives. |
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