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Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration

Overview of attention for article published in Virology Journal, December 2016
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Title
Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration
Published in
Virology Journal, December 2016
DOI 10.1186/s12985-016-0665-5
Pubmed ID
Authors

Daniel Stern, Victoria A. Olson, Scott K. Smith, Marko Pietraszczyk, Lilija Miller, Peter Miethe, Brigitte G. Dorner, Andreas Nitsche

Abstract

The rapid and reliable detection of infectious agents is one of the most challenging tasks in scenarios lacking well-equipped laboratory infrastructure, like diagnostics in rural areas of developing countries. Commercially available point-of-care diagnostic tests for emerging and rare diseases are particularly scarce. In this work we present a point-of-care test for the detection of Orthopoxviruses (OPV). The OPV ABICAP assay detects down to 1 × 10(4) plaque forming units/mL of OPV particles within 45 min. It can be applied to clinical material like skin crusts and detects all zoonotic OPV infecting humans, including Vaccinia, Cowpox, Monkeypox, and most importantly Variola virus. Given the high sensitivity and the ease of handling, the novel assay could be highly useful for on-site diagnostics of suspected Monkeypox virus infections in areas lacking proper laboratory infrastructure as well as rapid on-site testing of suspected bioterrorism samples.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 11%
Researcher 6 11%
Student > Master 5 9%
Student > Bachelor 4 7%
Other 4 7%
Other 8 15%
Unknown 22 40%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 13%
Immunology and Microbiology 5 9%
Medicine and Dentistry 5 9%
Agricultural and Biological Sciences 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 6 11%
Unknown 27 49%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
All research outputs
#14,289,166
of 22,912,409 outputs
Outputs from Virology Journal
#1,614
of 3,054 outputs
Outputs of similar age
#227,733
of 419,352 outputs
Outputs of similar age from Virology Journal
#13
of 30 outputs
Altmetric has tracked 22,912,409 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,352 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.