Title |
Profibrotic potential of Prominin-1+epithelial progenitor cells in pulmonary fibrosis
|
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Published in |
Respiratory Research, December 2011
|
DOI | 10.1186/1465-9921-12-126 |
Pubmed ID | |
Authors |
Przemyslaw Blyszczuk, Davide Germano, Sokrates Stein, Holger Moch, Christian M Matter, Beatrice Beck-Schimmer, Thomas F Lüscher, Urs Eriksson, Gabriela Kania |
Abstract |
In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibrosis. Regenerative potential of pulmonary and extra-pulmonary stem and progenitor cells raised the hope for successful treatment option against pulmonary fibrosis. Herein, we addressed the contribution of lung microenvironment and prominin-1(+) bone marrow-derived epithelial progenitor cells in the mouse model of bleomycin-induced experimental pulmonary fibrosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 19% |
Lecturer | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Professor | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 7 | 33% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Sports and Recreations | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 19% |