Title |
Polyethylene glycol as a cause of anaphylaxis
|
---|---|
Published in |
Allergy, Asthma & Clinical Immunology, December 2016
|
DOI | 10.1186/s13223-016-0172-7 |
Pubmed ID | |
Authors |
Katharina Wylon, Sabine Dölle, Margitta Worm |
Abstract |
Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction. Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be underdiagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity. |
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Geographical breakdown
Country | Count | As % |
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Turkey | 21 | 11% |
United States | 18 | 9% |
United Kingdom | 9 | 5% |
Canada | 6 | 3% |
Romania | 3 | 2% |
Australia | 3 | 2% |
Germany | 2 | 1% |
Burkina Faso | 1 | <1% |
Malaysia | 1 | <1% |
Other | 3 | 2% |
Unknown | 126 | 65% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 176 | 91% |
Scientists | 9 | 5% |
Practitioners (doctors, other healthcare professionals) | 6 | 3% |
Science communicators (journalists, bloggers, editors) | 2 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 81 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 13% |
Researcher | 11 | 13% |
Student > Master | 8 | 10% |
Student > Bachelor | 8 | 10% |
Student > Postgraduate | 5 | 6% |
Other | 14 | 17% |
Unknown | 25 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 5 | 6% |
Immunology and Microbiology | 4 | 5% |
Other | 12 | 15% |
Unknown | 29 | 35% |