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Uncovering neglected subtypes and zoonotic transmission of Hepatitis E virus (HEV) in Brazil

Overview of attention for article published in Virology Journal, May 2023
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  • High Attention Score compared to outputs of the same age and source (84th percentile)

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Title
Uncovering neglected subtypes and zoonotic transmission of Hepatitis E virus (HEV) in Brazil
Published in
Virology Journal, May 2023
DOI 10.1186/s12985-023-02047-6
Pubmed ID
Authors

Debora Regina Lopes dos Santos, Ricardo Durães-Carvalho, Noemi Rovaris Gardinali, Lais Ceschini Machado, Vanessa Salete de Paula, Gabriel da Luz Wallau, Jaqueline Mendes de Oliveira, Lindomar José Pena, Marcelo Alves Pinto, Laura Helena Vega Gonzalez Gil, Edmilson Ferreira de Oliveira-Filho

Abstract

Hepatitis E virus (HEV) circulation in humans and swine has been extensively studied in South America over the last two decades. Nevertheless, only 2.1% of reported HEV strains are available as complete genome sequences. Therefore, many clinical, epidemiological, and evolutionary aspects of circulating HEV in the continent still need to be clarified. Here, we conducted a retrospective evolutionary analysis of one human case and six swine HEV strains previously reported in northeastern, southern, and southeastern Brazil. We obtained two complete and four nearly complete genomic sequences. Evolutionary analysis comparing the whole genomic and capsid gene sequences revealed high genetic variability. This included the circulation of at least one unrecognized unique South American subtype. Our results corroborate that sequencing the whole capsid gene could be used as an alternative for HEV subtype assignment in the absence of complete genomic sequences. Moreover, our results substantiate the evidence for zoonotic transmission by comparing a larger genomic fragment recovered from the sample of the autochthonous human hepatitis E case. Further studies should continuously investigate HEV genetic diversity and zoonotic transmission of HEV in South America.

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X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Postgraduate 2 22%
Lecturer 1 11%
Professor 1 11%
Student > Doctoral Student 1 11%
Other 0 0%
Unknown 1 11%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 3 33%
Biochemistry, Genetics and Molecular Biology 3 33%
Immunology and Microbiology 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2023.
All research outputs
#6,646,870
of 24,721,757 outputs
Outputs from Virology Journal
#674
of 3,292 outputs
Outputs of similar age
#112,267
of 390,116 outputs
Outputs of similar age from Virology Journal
#13
of 79 outputs
Altmetric has tracked 24,721,757 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,292 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 390,116 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.