Title |
Intermolecular interactions of the malate synthase of Paracoccidioides spp
|
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Published in |
BMC Microbiology, May 2013
|
DOI | 10.1186/1471-2180-13-107 |
Pubmed ID | |
Authors |
Karine Martins de Oliveira, Benedito Rodrigues da Silva Neto, Juliana Alves Parente, Roosevelt Alves da Silva, Guilherme Oliveira Quintino, Aline Raquel Voltan, Maria José Soares Mendes-Giannini, Célia Maria de Almeida Soares, Maristela Pereira |
Abstract |
The fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules. Paracoccidioides malate synthase (PbMLS) is important in the infectious process of Paracoccidioides spp because the transcript is up-regulated during the transition from mycelium to yeast and in yeast cells during phagocytosis by murine macrophages. In addition, PbMLS acts as an adhesin in Paracoccidioides spp. The evidence for the multifunctionality of PbMLS indicates that it could interact with other proteins from the fungus and host. The objective of this study was to identify and analyze proteins that possibly bind to PbMLS (PbMLS-interacting proteins) because protein interactions are intrinsic to cell processes, and it might be possible to infer the function of a protein through the identification of its ligands. |
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