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Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies

Overview of attention for article published in BMC Cardiovascular Disorders, October 2016
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Title
Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies
Published in
BMC Cardiovascular Disorders, October 2016
DOI 10.1186/s12872-016-0379-z
Pubmed ID
Authors

Tian Zuo, Xuehui Liu, Lu Jiang, Shuai Mao, Xin Yin, Liheng Guo

Abstract

Hyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; however, the results from prospective studies are conflicting. The objective of this study was to assess the association between hyperuricemia and risk of CHD mortality by performing a meta-analysis. Pubmed and Embase were searched for relevant prospective cohort studies published until July 2015. Studies were included only if they reported data on CHD mortality related to hyperuricemia in a general population. The pooled adjusted relative risk (RR) was calculated using a random-effects model. A total of 14 studies involving 341 389 adults were identified. Hyperuricemia was associated with an increased risk of CHD mortality (RR: 1.14; 95 % CI: 1.06-1.23) and all-cause mortality (RR: 1.20; 95 % CI: 1.13-1.28). For each increase of 1 mg/dl of serum uric acid (SUA), the overall risks of CHD and all-cause mortality increased by 20 and 9 %, respectively. According to the gender subgroup analyses, hyperuricemia increased the risk of CHD mortality in women (RR: 1.47; 95 % CI: 1.21-1.73) compared to men (RR: 1.10; 95 % CI: 1.00-1.19). The risk of all-cause mortality was greater in women. Hyperuricemia may modestly increase the risk of CHD and all-cause mortality. Future research is needed to determine whether urate-lowering therapy has beneficial effects for reducing CHD mortality.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 12%
Student > Bachelor 9 11%
Other 8 10%
Student > Postgraduate 8 10%
Student > Master 6 7%
Other 14 17%
Unknown 26 32%
Readers by discipline Count As %
Medicine and Dentistry 37 46%
Biochemistry, Genetics and Molecular Biology 4 5%
Nursing and Health Professions 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Unspecified 2 2%
Other 8 10%
Unknown 26 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2016.
All research outputs
#13,262,892
of 22,914,829 outputs
Outputs from BMC Cardiovascular Disorders
#546
of 1,622 outputs
Outputs of similar age
#160,309
of 313,736 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#8
of 33 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,622 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,736 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.