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Genetic diversity of HA1 domain of heammaglutinin gene of influenza A(H1N1)pdm09 in Tunisia

Overview of attention for article published in Virology Journal, May 2013
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Title
Genetic diversity of HA1 domain of heammaglutinin gene of influenza A(H1N1)pdm09 in Tunisia
Published in
Virology Journal, May 2013
DOI 10.1186/1743-422x-10-150
Pubmed ID
Authors

Awatef El Moussi, Mohamed Ali Ben Hadj Kacem, Francisco Pozo, Juan Ledesma, Maria Teresa Cuevas, Inmaculada Casas, Amine Slim

Abstract

We present major results concerning isolation and determination of the nucleotide sequence of hemagglutinin (HA1) of the pandemic (H1N1)pdm09 influenza viruses found in Tunisia. Amino acid analysis revealed minor amino acid changes in the antigenic or receptor-binding domains. We found mutations that were also present in 1918 pandemic virus, which includes S183P in 4 and S185T mutation in 19 of 27 viruses analyzed from 2011, while none of the 2009 viruses carried these mutations. Also two specific amino acid differences into N-glycosylation sites (N288T and N276H) were detected. The phylogenetic analysis revealed that the majority of the Tunisian isolates clustered with clade A/St. Petersburg/27/2011 viruses characterized by D97N and S185T mutations. However it also reveals a trend of 2010 strains to accumulate amino acid variation and form new phylogenetic clade with three specific amino acid substitutions: V47I, E172K and K308E.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 26%
Student > Ph. D. Student 4 15%
Professor 3 11%
Student > Bachelor 3 11%
Other 2 7%
Other 4 15%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 19%
Medicine and Dentistry 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Immunology and Microbiology 4 15%
Veterinary Science and Veterinary Medicine 1 4%
Other 3 11%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2013.
All research outputs
#15,271,909
of 22,710,079 outputs
Outputs from Virology Journal
#1,935
of 3,034 outputs
Outputs of similar age
#120,778
of 195,184 outputs
Outputs of similar age from Virology Journal
#65
of 99 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,034 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.