Title |
Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography
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Published in |
BMC Cancer, April 2013
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DOI | 10.1186/1471-2407-13-218 |
Pubmed ID | |
Authors |
Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew, Elizabeth A McNiel |
Abstract |
Human and feline head and neck squamous cell carcinoma (HNSCC) share histology, certain molecular features, as well as locally aggressive and highly recurrent clinical behavior. In human HNSCC, the presence of significant hypoxia within these tumors is considered an important factor in the development of a more aggressive phenotype and poor response to therapy. We hypothesized that feline head and neck tumors, particularly HNSCC, would exhibit hypoxia and that ⁶⁴Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) positron emission tomography/computed tomography (PET/CT) would permit detection of intratumoral hypoxia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 10 | 20% |
Student > Ph. D. Student | 9 | 18% |
Student > Master | 6 | 12% |
Other | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 8 | 16% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 33% |
Veterinary Science and Veterinary Medicine | 9 | 18% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Agricultural and Biological Sciences | 3 | 6% |
Unspecified | 1 | 2% |
Other | 4 | 8% |
Unknown | 13 | 25% |