Title |
ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response
|
---|---|
Published in |
BMC Research Notes, May 2013
|
DOI | 10.1186/1756-0500-6-203 |
Pubmed ID | |
Authors |
Juzoh Umemori, Keizo Takao, Hisatsugu Koshimizu, Satoko Hattori, Tamio Furuse, Shigeharu Wakana, Tsuyoshi Miyakawa |
Abstract |
The Grin1 (glutamate receptor, ionotropic, NMDA1) gene expresses a subunit of N-methyl-D-aspartate (NMDA) receptors that is considered to play an important role in excitatory neurotransmission, synaptic plasticity, and brain development. Grin1 is a candidate susceptibility gene for neuropsychiatric disorders, including schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). In our previous study, we examined an N-ethyl-N-nitrosourea (ENU)-generated mutant mouse strain (Grin1(Rgsc174)/Grin1+) that has a non-synonymous mutation in Grin1. These mutant mice showed hyperactivity, increased novelty-seeking to objects, and abnormal social interactions. Therefore, Grin1(Rgsc174)/Grin1+ mice may serve as a potential animal model of neuropsychiatric disorders. However, other behavioral characteristics related to these disorders, such as working memory function and sensorimotor gating, have not been fully explored in these mutant mice. In this study, to further investigate the behavioral phenotypes of Grin1(Rgsc174)/Grin1+ mice, we subjected them to a comprehensive battery of behavioral tests. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 8 | 15% |
Researcher | 8 | 15% |
Other | 4 | 7% |
Student > Master | 4 | 7% |
Other | 11 | 20% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 22% |
Neuroscience | 11 | 20% |
Medicine and Dentistry | 9 | 16% |
Psychology | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 2 | 4% |
Unknown | 14 | 25% |