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Thirty years on: HIV receptor gymnastics and the prevention of infection

Overview of attention for article published in BMC Biology, May 2013
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17 X users

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Title
Thirty years on: HIV receptor gymnastics and the prevention of infection
Published in
BMC Biology, May 2013
DOI 10.1186/1741-7007-11-57
Pubmed ID
Authors

Robin A Weiss

Abstract

During 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors--CD4, CCR5 and CXCR4--has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome (AIDS). Studying how the HIV envelope glycoproteins interact with the receptors led to anti-retroviral drugs based on blocking the docking or fusion of virus to the host cell. Genetic polymorphisms of CCR5 determine resistance to HIV infection and the rate of progression to AIDS. Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development.

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The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Portugal 1 1%
Unknown 85 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 18%
Student > Ph. D. Student 15 17%
Researcher 13 15%
Student > Master 9 10%
Student > Postgraduate 8 9%
Other 13 15%
Unknown 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 31%
Medicine and Dentistry 14 16%
Biochemistry, Genetics and Molecular Biology 14 16%
Immunology and Microbiology 6 7%
Chemistry 5 6%
Other 5 6%
Unknown 16 18%