Title |
Diurnal variation of phenylalanine and tyrosine concentrations in adult patients with phenylketonuria: subcutaneous microdialysis is no adequate tool for the determination of amino acid concentrations
|
---|---|
Published in |
Nutrition Journal, May 2013
|
DOI | 10.1186/1475-2891-12-60 |
Pubmed ID | |
Authors |
Sarah C Grünert, Corinna M Brichta, Andreas Krebs, Hans-Willi Clement, Reinhold Rauh, Christian Fleischhaker, Klaus Hennighausen, Jörn Oliver Sass, K Otfried Schwab |
Abstract |
Metabolic control and dietary management of patients with phenylketonuria (PKU) are based on single blood samples obtained at variable intervals. Sampling conditions are often not well-specified and intermittent variation of phenylalanine concentrations between two measurements remains unknown. We determined phenylalanine and tyrosine concentrations in blood over 24 hours. Additionally, the impact of food intake and physical exercise on phenylalanine and tyrosine concentrations was examined. Subcutaneous microdialysis was evaluated as a tool for monitoring phenylalanine and tyrosine concentrations in PKU patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 21% |
Other | 4 | 11% |
Researcher | 4 | 11% |
Student > Master | 4 | 11% |
Student > Postgraduate | 2 | 5% |
Other | 3 | 8% |
Unknown | 13 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 18% |
Nursing and Health Professions | 4 | 11% |
Agricultural and Biological Sciences | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Mathematics | 1 | 3% |
Other | 7 | 18% |
Unknown | 13 | 34% |