Title |
Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development
|
---|---|
Published in |
Molecular Brain, May 2013
|
DOI | 10.1186/1756-6606-6-25 |
Pubmed ID | |
Authors |
Yuichi Hiraoka, Okiru Komine, Mai Nagaoka, Ning Bai, Katsuto Hozumi, Kohichi Tanaka |
Abstract |
Bergmann glia (BG) are unipolar cerebellar astrocytes. The somata of mature BG reside in the Purkinje cell layer and extend radially arranged processes to the pial surface. BG have multiple branched processes, which enwrap the synapses of Purkinje cell dendrites. They migrate from the ventricular zone and align next to the Purkinje cell layer during development. Previously, we reported that Notch1, Notch2, and RBPj genes in the BG play crucial roles in the monolayer formation and morphogenesis of BG. However, it remains to be determined which ligand activates Nocth1 and Notch 2 on BG. Delta-like 1 (Dll1) is a major ligand of Notch receptors that is expressed in the developing cerebellum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Italy | 1 | 3% |
Unknown | 37 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 20% |
Student > Ph. D. Student | 6 | 15% |
Student > Master | 6 | 15% |
Student > Bachelor | 2 | 5% |
Professor | 2 | 5% |
Other | 6 | 15% |
Unknown | 10 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 28% |
Neuroscience | 8 | 20% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Medicine and Dentistry | 3 | 8% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 28% |