Title |
Increased replication of CD4+ naive T cells and changes in T cell homeostasis in a case of acute exacerbation of juvenile idiopathic arthritis: a case comparison study
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Published in |
Journal of Medical Case Reports, May 2013
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DOI | 10.1186/1752-1947-7-135 |
Pubmed ID | |
Authors |
Giovanni Almanzar, Manuela Zlamy, Christian Koppelstaetter, Andrea Brunner, Verena Jeller, Christina Duftner, Christian Dejaco, Juergen Brunner, Martina Prelog |
Abstract |
Juvenile idiopathic arthritis is a heterogeneous T cell-mediated autoimmune disease with symptoms of premature aging of the immune system (immunosenescence). The present work is an investigation of immunosenescence parameters, such as quantity of naive and CD28- T cells, T cell receptor excision circles, relative telomere length and alterations of peripheral T cell replication, and was performed via comparison of a case of acute exacerbation of juvenile idiopathic arthritis against six patients with juvenile idiopathic arthritis with disease remission and six age-matched healthy donors over a follow-up course of 12 months. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 5% |
Canada | 1 | 5% |
Unknown | 20 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 14% |
Student > Bachelor | 3 | 14% |
Student > Master | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Researcher | 3 | 14% |
Other | 3 | 14% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 36% |
Agricultural and Biological Sciences | 5 | 23% |
Immunology and Microbiology | 2 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Unknown | 5 | 23% |