Title |
Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment
|
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Published in |
BMC Genomics, May 2013
|
DOI | 10.1186/1471-2164-14-348 |
Pubmed ID | |
Authors |
Ryan Y Wong, Sarah E Oxendine, John Godwin |
Abstract |
Stress and anxiety-related behaviors are seen in many organisms. Studies have shown that in humans and other animals, treatment with selective serotonin reuptake inhibitors (e.g. fluoxetine) can reduce anxiety and anxiety-related behaviors. The efficacies and side effects, however, can vary between individuals. Fluoxetine can modulate anxiety in a stereospecific manner or with equal efficacy regardless of stereoisomer depending on the mechanism of action (e.g. serotonergic or GABAergic effects). Zebrafish are an emerging and valuable translational model for understanding human health related issues such as anxiety. In this study we present data showing the behavioral and whole brain transcriptome changes with fluoxetine treatment in wild-derived zebrafish and suggest additional molecular mechanisms of this widely-prescribed drug. |
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