Title |
COHELLP: collaborative randomized controlled trial on corticosteroids in HELLP syndrome
|
---|---|
Published in |
Reproductive Health, May 2013
|
DOI | 10.1186/1742-4755-10-28 |
Pubmed ID | |
Authors |
Leila Katz, Melania Amorim, João P Souza, Samira M Haddad, José G Cecatti, COHELLP Study Group |
Abstract |
Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is one of the most severe forms of preeclampsia and aggravates both maternal and perinatal prognosis. The systematic review available in Cochrane Library compared corticosteroid (dexamethasone, betamethasone, or prednisolone) given during pregnancy, just after delivery or in the postnatal period, or both before and after birth, with placebo or no treatment. Those receiving steroids showed significantly greater improvement in platelet counts which was greater for those receiving dexamethasone than those receiving betamethasone. There was no clear evidence of any effect of corticosteroids on substantive clinical outcomes. These benefits appear to be greater in Class I HELLP syndrome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 3% |
Nigeria | 1 | 1% |
New Zealand | 1 | 1% |
Unknown | 85 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 16% |
Student > Postgraduate | 9 | 10% |
Other | 8 | 9% |
Researcher | 8 | 9% |
Student > Doctoral Student | 7 | 8% |
Other | 22 | 24% |
Unknown | 22 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 49% |
Nursing and Health Professions | 7 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Neuroscience | 3 | 3% |
Business, Management and Accounting | 3 | 3% |
Other | 8 | 9% |
Unknown | 22 | 24% |