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Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

Overview of attention for article published in BMC Genomics, May 2013
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Citations

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Title
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis
Published in
BMC Genomics, May 2013
DOI 10.1186/1471-2164-14-339
Pubmed ID
Authors

Li Chen, Qun Yue, Xinyu Zhang, Meichun Xiang, Chengshu Wang, Shaojie Li, Yongsheng Che, Francisco Javier Ortiz-López, Gerald F Bills, Xingzhong Liu, Zhiqiang An

Abstract

The antifungal therapy caspofungin is a semi-synthetic derivative of pneumocandin B0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was the first member of the echinocandin class approved for human therapy. The nonribosomal peptide synthetase (NRPS)-polyketide synthases (PKS) gene cluster responsible for pneumocandin biosynthesis from G. lozoyensis has not been elucidated to date. In this study, we report the elucidation of the pneumocandin biosynthetic gene cluster by whole genome sequencing of the G. lozoyensis wild-type strain ATCC 20868.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Malaysia 1 <1%
Brazil 1 <1%
Unknown 109 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 30%
Researcher 21 19%
Student > Bachelor 13 12%
Student > Master 10 9%
Professor 5 4%
Other 18 16%
Unknown 11 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 45%
Biochemistry, Genetics and Molecular Biology 24 21%
Chemistry 11 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Chemical Engineering 2 2%
Other 8 7%
Unknown 14 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2013.
All research outputs
#20,194,150
of 22,711,242 outputs
Outputs from BMC Genomics
#9,250
of 10,625 outputs
Outputs of similar age
#170,716
of 195,766 outputs
Outputs of similar age from BMC Genomics
#108
of 118 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,625 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.