Title |
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis
|
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Published in |
BMC Genomics, May 2013
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DOI | 10.1186/1471-2164-14-339 |
Pubmed ID | |
Authors |
Li Chen, Qun Yue, Xinyu Zhang, Meichun Xiang, Chengshu Wang, Shaojie Li, Yongsheng Che, Francisco Javier Ortiz-López, Gerald F Bills, Xingzhong Liu, Zhiqiang An |
Abstract |
The antifungal therapy caspofungin is a semi-synthetic derivative of pneumocandin B0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was the first member of the echinocandin class approved for human therapy. The nonribosomal peptide synthetase (NRPS)-polyketide synthases (PKS) gene cluster responsible for pneumocandin biosynthesis from G. lozoyensis has not been elucidated to date. In this study, we report the elucidation of the pneumocandin biosynthetic gene cluster by whole genome sequencing of the G. lozoyensis wild-type strain ATCC 20868. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
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Researcher | 21 | 19% |
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Professor | 5 | 4% |
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Unknown | 11 | 10% |
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Other | 8 | 7% |
Unknown | 14 | 13% |