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Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study

Overview of attention for article published in Nutrition Journal, December 2016
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Title
Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study
Published in
Nutrition Journal, December 2016
DOI 10.1186/s12937-016-0221-6
Pubmed ID
Authors

Haijiang Dai, Weijun Wang, Xiaohong Tang, Ruifang Chen, Zhiheng Chen, Yao Lu, Hong Yuan

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and its prevalence is likely to rise even further. To help understand the pathogenesis and early prevention of progressive NAFLD, this large-scale study was designed to explore the potential association between homocysteine and the prevalence of NAFLD. A total of 7203 subjects aged 18 years or older were enrolled in this cross-sectional study. The association of homocysteine with the prevalence of NAFLD, in the total sample and stratified by subgroups, was examined using multiple logistic regression analyses. Subjects in the higher quartiles of homocysteine had a higher prevalence of NAFLD. After multivariate adjustment, the odds ratio (OR) for NAFLD in the highest compared with the lowest quartile of homocysteine was 2.08 (95% confidence interval [CI] 1.61, 2.67). Moreover, in the subgroup analyses, we found an effect modification by gender, body mass index (BMI) and smoking status on the association between homocysteine and the prevalence of NAFLD (P for interaction: 0.001, 0.002 and <0.001, respectively). A stronger association was observed in female, obese and non-smoking adults than in male, normal weight and smoking subjects. Homocysteine was significantly associated with the prevalence of NAFLD, particularly in female, obese or non-smoking adults.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 16%
Student > Ph. D. Student 6 12%
Researcher 4 8%
Student > Master 4 8%
Student > Postgraduate 3 6%
Other 7 14%
Unknown 18 36%
Readers by discipline Count As %
Medicine and Dentistry 10 20%
Biochemistry, Genetics and Molecular Biology 6 12%
Nursing and Health Professions 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Psychology 2 4%
Other 4 8%
Unknown 21 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2022.
All research outputs
#15,138,399
of 23,283,373 outputs
Outputs from Nutrition Journal
#1,136
of 1,441 outputs
Outputs of similar age
#243,156
of 421,240 outputs
Outputs of similar age from Nutrition Journal
#14
of 16 outputs
Altmetric has tracked 23,283,373 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,441 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.